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Is Personality More Nature or More Nurture? Behavioral and Molecular Genetics
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The molecular genetic architecture of human personality: beyond self-report questionnaires.
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Correspondence to C.
Quantitative and Molecular Genetics of Animal Personality - Chicago Scholarship
Robert Cloninger. Reprints and Permissions. Frontiers in Psychology Molecular Psychiatry Advanced search. Skip to main content. Subjects Diagnostic markers Genetics Neuroscience Psychology. Introduction Strong evidence for substantial heritability of human personality comes from family, twin, and adoption studies [ 1 ]. Subjects and methods Description of the samples Our discovery sample was the Young Finns Study, an epidemiological study of healthy Finnish children followed regularly from ages, 3—18 years to ages, 35—50 years [ 34 ].
Personality assessment All subjects completed the TCI to assess seven heritable dimensions of personality [ 23 , 47 ]. Personality health indices People at risk of unhealthy personality were identified as the bottom decile of the sum of TCI self-directedness and cooperativeness [ 48 ]. Computational procedures The cluster analyses used the validated Generalized Factorization Method, which utilizes deep non-negative matrix factorization NMF to uncover naturally occurring i.
Full size image. Table 3 The strength of the genotypic—phenotypic relationships among SNP and character sets and their corresponding health measurements Full size table. Discussion This is the first data-driven study to examine the genotypic—phenotypic architecture of human character traits, which are the self-regulatory components of personality that modulate physical, mental, and social well-being [ 48 , 65 ]. Strengths and limitations Our unbiased analytical PGMRA method used deep cluster analysis to identify association between possibly interactive sets of features instead of between individual SNPs or character traits.
Conclusions and recommendations for future research We were able to characterize and replicate the complexity of the genotypic—phenotypic risk architecture of self-regulatory character traits in three large samples. References 1. Article Google Scholar 2. Article Google Scholar 3. PubMed Google Scholar 4.
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